• 靶点：
• JAK2

• 简介：
• >>EGFR tyrosine kinase inhibitor resistance;>>Chemokine signaling pathway;>>PI3K-Akt signaling pathway;>>Necroptosis;>>Signaling pathways regulating pluripotency of stem cells;>>JAK-STAT signaling pathway;>>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>Cholinergic synapse;>>Prolactin signaling pathway;>>Adipocytokine signaling pathway;>>AGE-RAGE signaling pathway in diabetic complications;>>Growth hormone synthesis, secretion and action;>>Leishmaniasis;>>Toxoplasmosis;>>Tuberculosis;>>Hepatitis B;>>Influenza A;>>Kaposi sarcoma-associated herpesvirus infection;>>Herpes simplex virus 1 infection;>>Pathways in cancer;>>Chemical carcinogenesis - receptor activation;>>PD-L1 expression and PD-1 checkpoint pathway in cancer;>>Lipid and atherosclerosis

• 基因名称：
• JAK2

• 蛋白名称：
• JAK2

• Human Gene Id：
• 3717

• Human Swiss Prot No：
• O60674

• Mouse Gene Id：
• 16452

• Mouse Swiss Prot No：
• Q62120

• Rat Gene Id：
• 24514

• Rat Swiss Prot No：
• Q62689

• 特异性：
• endogenous

• 组成：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• 来源：
• Monoclonal, rabbit, IgG, Kappa

• 稀释：
• IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;

• 纯化工艺：
• Protein A

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)

• 分子量：
• 131kD

• 实测条带：
• 131kD

• 背景：
• This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Chromosomal aberrations involving JAK2 are found in both chronic and acute forms of eosinophilic, lymphoblastic and myeloid leukemia. Translocation t(8;9)(p22;p24) with PCM1 links the protein kinase domain of JAK2 to the major portion of PCM1. Translocation t(9;12)(p24;p13) with ETV6.,disease:Defects in JAK2 are a cause of acute myelogenous leukemia (AML) [MIM:601626]. AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development.,disease:Defects in JAK2 are a cause of susceptibility to Budd-Chiari syndrome [MIM:600880]. Budd-Chiari syndrome is a spectrum of disease states, including anatomic abnormalities and hypercoagulable disorders, resulting in hepatic venous outflow occlusion. Clinical manifestations observed in the majority of patients incl

• 细胞定位：
• Cytoplasm, Nucleus

• 组织表达：
• Ubiquitously expressed throughout most tissues.

Shenlian extract attenuates myocardial ischaemia-reperfusion injury via inhibiting M1 macrophage polarization by silencing miR-155
货号：YM8330

Shaoyao-Gancao Decoction Promoted Microglia M2 Polarization via the IL-13-Mediated JAK2/STAT6 Pathway to Alleviate Cerebral Ischemia-Reperfusion Injury WB Rat 1:400 penumbra tissue/
货号：YM8330

Network pharmacology analysis and experimental validation to explore the mechanism of Shenlian extract on myocardial ischemia J Ethnopharmacol. 2022 Apr;288:114973. WB Rat 1:1000 Heart
货号：YM8330

Glycerophospholipid metabolism is involved in rheumatoid arthritis pathogenesis by regulating the IL-6/JAK signaling pathway Biochem Bioph Res Co. 2022 Feb;:. WB Human 1:1000
货号：YM8330

Glycogen metabolism regulates macrophage-mediated acute inflammatory responses. Nature Communications Nat Commun. 2020 Apr;11(1):1-16 WB Mouse 1:1000 BMDMs
货号：YM8330

HIF‐1α facilitates osteocyte‐mediated osteoclastogenesis by activating JAK2/STAT3 pathway in vitro. JOURNAL OF CELLULAR PHYSIOLOGY 2019 Apr 29 WB Mouse 1:500 MLO-Y4 cell
货号：YM8330

Carbon Ion Therapy Inhibits Esophageal Squamous Cell Carcinoma Metastasis by Upregulating STAT3 Through the JAK2/STAT3 Signaling Pathway. Frontiers in Public Health Front Public Health. 2020 Nov;0:801 WB Human 1:1000 ECA109 cell， KYSE150 cell
货号：YM8330

Mitochondrial dysfunction-mediated decline in angiogenic capacity of endothelial progenitor cells is associated with capillary rarefaction in patients with hypertension via downregulation of CXCR4/JAK2/SIRT5 signaling. EBioMedicine Ebiomedicine. 2019 Apr;42:64 WB Rat 1:1000 EPCs
货号：YM8330

Mitochondrial dysfunction-mediated decline in angiogenic capacity of endothelial progenitor cells is associated with capillary rarefaction in patients with hypertension via downregulation of CXCR4/JAK2/SIRT5 signaling. EBioMedicine Ebiomedicine. 2019 Apr;42:64 WB Rat 1:1000 EPCs
货号：YM8330

miRNA-331-3p Affects the Proliferation, Metastasis, and Invasion of Osteosarcoma through SOCS1/JAK2/STAT3 Journal of Oncology Bing Wu WB Mouse
货号：YM8330

Shenlian extract improves atherosclerosis by relieving adventitial inflammation. JOURNAL OF ETHNOPHARMACOLOGY Xiaoxin Zhu WB Rat vascular adventitial fibroblasts (VAFs)
货号：YM8330

Overexpression of miR-506-3p reversed doxorubicin resistance in drug-resistant osteosarcoma cells Frontiers in Pharmacology Wang Xinru WB Human 1:1000 U-2OS/Dox cell
货号：YM8330

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