• 靶点：
• Catenin-β

• 简介：
• >>Rap1 signaling pathway;>>Wnt signaling pathway;>>Hippo signaling pathway;>>Focal adhesion;>>Adherens junction;>>Signaling pathways regulating pluripotency of stem cells;>>Leukocyte transendothelial migration;>>Melanogenesis;>>Thyroid hormone signaling pathway;>>Cushing syndrome;>>Alcoholic liver disease;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases;>>Bacterial invasion of epithelial cells;>>Salmonella infection;>>Hepatitis C;>>Human cytomegalovirus infection;>>Human papillomavirus infection;>>Kaposi sarcoma-associated herpesvirus infection;>>Pathways in cancer;>>Proteoglycans in cancer;>>Colorectal cancer;>>Endometrial cancer;>>Prostate cancer;>>Thyroid cancer;>>Basal cell carcinoma;>>Breast cancer;>>Hepatocellular carcinoma;>>Gastric cancer;>>Arrhythmogenic right ventricular cardiomyopathy;>>Fluid shear stress and atherosclerosis

• 基因名称：
• CTNNB1 CTNNB OK/SW-cl.35 PRO2286

• 蛋白名称：
• Catenin-β;b-catenin;Beta catenin;Beta-catenin;Cadherin associated protein;Catenin (cadherin associated protein), beta 1, 88 kDa;Catenin beta 1;Catenin beta-1;CATNB;CHBCAT;CTNB1_HUMAN;CTNNB;CTNNB1;DKFZ

• Human Gene Id：
• 1499

• Human Swiss Prot No：
• P35222

• 特异性：
• endogenous

• 组成：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• 来源：
• Monoclonal, rabbit, IgG, Kappa

• 稀释：
• IHC 1:1000-1:5000;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;

• 纯化工艺：
• Protein A

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CTNNB1;CTNNB;OK/SW-cl.35;Catenin beta-1;Beta-catenin

• 分子量：
• 84kD

• 实测条带：
• 96kD

• 背景：
• The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016],

• 功能：
• disease:A chromosomal rearrangement involving CTNNB1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1.,disease:Activating mutations in CTNNB1 have oncogenic activity resulting in tumor development. Somatic mutations are found in various tumor types, including colon cancers, ovarian and prostate carcinomas, hepatoblastoma (HB), hepatocellular carcinoma (HCC). HBs are malignant embryonal tumors mainly affecting young children in the first three years of life.,disease:Defects in CTNNB1 are a cause of medulloblastoma (MDB) [MIM:155255]. MDB is a malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children.,disease:Defects in CTNNB1 are a cause of pilomatrixoma (PTR) [MIM:132600]; a common benign skin tum

• 细胞定位：
• Cytoplasm, Membrane

• 组织表达：
• Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Expressed in colon. Present in cortical neurons (at protein level). Expressed in breast cancer tissues (at protein level) (PubMed:29367600).

The Stem Cell Potential of O-2A Lineage Astroglia WB Rat 1:500 /iNLCs
货号：YM8174

PDGF-mediated PI3K/AKT/β-catenin signaling regulates gap junctions in corpus cavernosum smooth muscle cells. EXPERIMENTAL CELL RESEARCH Exp Cell Res. 2018 Jan;362:252 WB Rat 1:500 corpus cavernosum smooth muscle cells (CCSMCs)
货号：YM8174

Liraglutide regulates bone destruction and exhibits anti-inflammatory effects in periodontitis in vitro and in vivo. JOURNAL OF DENTISTRY J Dent. 2020 Mar;94:103310 WB Human hPDLCs
货号：YM8174

Attenuation of the degenerative effects of endothelin-1 on cartilaginous end plate cells by the endothelin receptor antagonist BQ-123 via the Wnt/β-catenin signaling pathway. Spine Journal Spine J. 2018 Sep;18:1669 WB Rabbit cartilaginous end plate cells (CECs)
货号：YM8174

PPARγ suppressed Wnt/β-catenin signaling pathway and its downstream effector SOX9 expression in gastric cancer cells. MEDICAL ONCOLOGY Med Oncol. 2015 Apr;32(4):1-6 WB Human 1:800 MKN-28 cell, SGC-7901 cell ,BGC-823 cell
货号：YM8174

The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation. PROTEIN JOURNAL Protein J. 2018 Apr;37(2):132-143 WB Human HEK293T cell, HeLa cell
货号：YM8174

Transcription factor YY1 mediates epithelial–mesenchymal transition through the TGFβ signaling pathway in bladder cancer. MEDICAL ONCOLOGY Med Oncol. 2020 Oct;37(10):1-10 WB Human T24 bladder cancer cells
货号：YM8174

Rnf25/AO7 positively regulates wnt signaling via disrupting Nkd1-Axin inhibitory complex independent of its ubiquitin ligase activity. Oncotarget Oncotarget. 2016 Apr 26; 7(17): 23850–23859 CoIP Human HEK293T cell
货号：YM8174

Epimedin B exhibits pigmentation by increasing tyrosinase family proteins expression, activity, and stability. Journal of Pharmaceutical Analysis Huali Wu WB Mouse B16F10 cell
货号：YM8174

Aerobic exercise training engages the canonical wnt pathway to improve pulmonary function and inflammation in COPD BMC Pulmonary Medicine Peijun Li WB Mouse 1:1000 lung tissue
货号：YM8174

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