• 靶点：
• COX2

• 简介：
• >>Arachidonic acid metabolism;>>Metabolic pathways;>>NF-kappa B signaling pathway;>>VEGF signaling pathway;>>C-type lectin receptor signaling pathway;>>IL-17 signaling pathway;>>TNF signaling pathway;>>Retrograde endocannabinoid signaling;>>Serotonergic synapse;>>Ovarian steroidogenesis;>>Oxytocin signaling pathway;>>Regulation of lipolysis in adipocytes;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases;>>Leishmaniasis;>>Human cytomegalovirus infection;>>Human papillomavirus infection;>>Kaposi sarcoma-associated herpesvirus infection;>>Pathways in cancer;>>Chemical carcinogenesis - DNA adducts;>>MicroRNAs in cancer;>>Small cell lung cancer

• 基因名称：
• PTGS2 COX2

• 蛋白名称：
• Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2)

• Human Gene Id：
• 5743

• Human Swiss Prot No：
• P35354

• 特异性：
• endogenous

• 组成：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• 来源：
• Monoclonal, rabbit, IgG, Kappa

• 稀释：
• IHC 1:100-1:500,WB 1:1000-1:5000,IF 1:200-1:1000,ELISA 1:5000-1:20000,

• 纯化工艺：
• Protein A

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 69kD

• 实测条带：
• 75kD

• 背景：
• Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009],

• 功能：
• catalytic activity:Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group per subunit.,disease:Likely to play a role in inflammatory diseases such as rheumatoid arthritis.,function:May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.,induction:By cytokines and mitogens.,miscellaneous:This enzyme acts both as a dioxygenase and as a peroxidase.,miscellaneous:This enzyme is the target of nonsteroidal anti-inflammatory drugs such as aspirin.,pathway:Lipid metabolism; prostaglandin biosynthesis.,similarity:Belongs to the prostaglandin G/H synthase family.,similarity:Contains 1 EGF-like domain.,subunit:Homodimer.,

• 细胞定位：
• Cytoplasm

• 组织表达：
• Endothelial cell,Epidermal keratinocytes in primary culture,Lung,Pe

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Nrf2-mediated redox balance alleviates LPS-induced vascular endothelial cell inflammation by inhibiting endothelial cell ferroptosis Scientific Reports Hou Huimin WB Human 1:1000 Human umbilical vein endothelial cells (HUVEC)
货号：YM8171

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