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Vimentin (ABT019) mouse mAb

货号：YM6969
应用：IHC;ELISA
种属：Human;Mouse;Rat;

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靶点：
Vimentin

简介：
>>Epstein-Barr virus infection;>>MicroRNAs in cancer

基因名称：
VIM

蛋白名称：
ERK5

Human Gene Id：
7431

Human Swiss Prot No：
P08670

免疫原：
Synthesized peptide derived from human Vimentin AA range: 400-466

特异性：
The antibody can specifically recognize human Vimentin protein.

组成：
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

来源：
Mouse, Monoclonal/IgG2b, kappa

稀释：
IHC 1:200-400. ELISA 1:500-5000

纯化工艺：
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

其他名称：
Vimentin

分子量：
53kD

实测条带：
54kD

背景：
This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.[provided by RefSeq, Jun 2009],

功能：
function:Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells.,online information:Vimentin entry,PTM:One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized.,sequence caution:Intron retention.,similarity:Belongs to the intermediate filament family.,subunit:Homopolymer. Interacts with HCV core protein. Interacts with LGSN and SYNM.,tissue specificity:Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines.,

细胞定位：
Cytoplasmic

组织表达：
Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines.

miR-942-5p Inhibits Proliferation, Metastasis, and Epithelial-Mesenchymal Transition in Colorectal Cancer by Targeting CCBE1. Biomed Research International Biomed Res Int. 2021;2021:9951405 WB Human 1 : 1000 HCT116 cell，LoVo cell
货号：YM6969

Zheng, Jing-Min, et al. "Pathological significance of C3aR signaling in the tumor cells of clear cell renal cell carcinoma: a clinical observation." (2020).
货号：YM6969