• 靶点：
• TSHB

• 简介：
• >>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Thyroid hormone synthesis;>>Regulation of lipolysis in adipocytes;>>Autoimmune thyroid disease

• 基因名称：
• TSHB

• 蛋白名称：
• Thyrotropin subunit beta (Thyroid-stimulating hormone subunit beta) (TSH-B) (TSH-beta) (Thyrotropin beta chain) (Thyrotropin alfa)

• Human Gene Id：
• 7252

• Human Swiss Prot No：
• P01222

• 免疫原：
• Synthesized peptide derived from human Thyroid-Stimulating Hormone(TSH) AA range: 50-138

• 特异性：
• The antibody can specifically recognize human TSH protein.

• 组成：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• 来源：
• Mouse, Monoclonal/IgG1, Lambda

• 稀释：
• IHC 1:200-400. IF 1:50-200. ELISA 1:500-5000

• 纯化工艺：
• The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 16kD

• 背景：
• The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013],

• 功能：
• function:Indispensable for the control of thyroid structure and metabolism.,online information:Clinical information on Thyrogen,online information:Thyroid-stimulating hormone entry,pharmaceutical:Available under the name Thyrogen (Genzyme). Used in combination with other tests to detect recurring or leftover thyroid cancer cells in patients with a history of certain types of thyroid cancer.,similarity:Belongs to the glycoprotein hormones subunit beta family.,subunit:Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.,

• 细胞定位：
• Cytoplasmic

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