PD-1 (ABT-PD1) mouse mAb

    • 货号:YM6208
    • 应用:IHC;ELISA
    • 种属:Human;
      • 靶点:
      • PD1
      • 简介:
      • >>Cell adhesion molecules;>>T cell receptor signaling pathway;>>PD-L1 expression and PD-1 checkpoint pathway in cancer
      • 基因名称:
      • PDCD1 PD1
      • 蛋白名称:
      • Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279)
      • Human Gene Id:
      • 5133
      • Human Swiss Prot No:
      • Q15116
      • 免疫原:
      • Synthesized peptide derived from human PD-1 AA range: 1-100
      • 特异性:
      • The antibody can specifically recognize human PD-1 protein.
      • 组成:
      • PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
      • 来源:
      • Mouse, Monoclonal/IgG1, kappa
      • 稀释:
      • IHC 1:200-400. ELISA 1:500-5000
      • 纯化工艺:
      • The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 分子量:
      • 32kD
      • 实测条带:
      • 56kD
      • 背景:
      • This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008],
      • 功能:
      • developmental stage:Induced at programmed cell death.,disease:Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.,function:Possible cell death inducer, in association with other factors.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Monomer.,
      • 细胞定位:
      • Membranous, Cytoplasmic
      • 组织表达:
      • Placenta,Pooled tissue,Uterine cervix,

      A four‐factor immune risk score signature predicts the clinical outcome of patients with spinal chordoma. Clinical and Translational Medicine Clin Transl Med. 2020 Mar;10(1):224-237 IF Human 1:10000 Spinal chordoma tumor tissue
      货号:YM6208

      • 产品图片
      • Human lymphoma tissue was stained with Anti-PD-1 (ABT-PD1) Antibody
      • Human lymphoma tissue was stained with Anti-PD-1 (ABT-PD1) Antibody
      • Human lymphoma tissue was stained with Anti-PD-1 (ABT-PD1) Antibody
      • Human tonsil tissue was stained with Anti-PD-1 (ABT-PD1) Antibody
      • Fluorescence multiplex immunohistochemical analysis of normal human appendix tissue (formalin-fixed paraffin-embedded section).The section was incubated in 3 rounds of staining; in the order of CK PAN .( Catalog no:YM6815 1/200 dilution), PD-1.(Catalog no: YM6208 1/200 dilution), Caldesmon pan. (Catalog no:YM6826 1/200 dilution),each using a separate fluorescent tyramide signal amplification system : Treble-Fluorescence immunohistochemical mouse/rabbit kit Catalog NO: RS0035 (pH9.0)
      • Zou, Ming‐Xiang, et al. "A four‐factor immune risk score signature predicts the clinical outcome of patients with spinal chordoma." Clinical and translational medicine 10.1 (2020): 224-237.