• 靶点：
• Cytokeratin 4

• 基因名称：
• KRT4 CYK4

• 蛋白名称：
• Keratin, type II cytoskeletal 4 (Cytokeratin-4) (CK-4) (Keratin-4) (K4) (Type-II keratin Kb4)

• Human Swiss Prot No：
• P19013

• 免疫原：
• Synthesized peptide derived from human Cytokeratin 4 AA range: 400-534

• 特异性：
• The antibody can specifically recognize human CK4 protein, and shows no cross reaction with CK5, 6, 7, 8, 14, 15, 17, 20.

• 组成：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• 来源：
• Mouse, Monoclonal/IgG1, kappa

• 稀释：
• IHC 1:200-1000. WB 1:500-2000. IF 1:100-500. ELISA 1:1000-5000

• 纯化工艺：
• Protein G

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CK 4；CK-4；CK4；CYK4；Cytokeratin 4；CytokeRatin-4；CytokeRatin4；FLJ31692；K2C4_HUMAN；K4；KeRatin 4；KeRatin；KeRatin type II cytoskeletal 4；KeRatin-4；KeRatin4；KRT 4；Krt4；type II cytoskeletal 4；Type-II keRatin Kb4

• 分子量：
• 57kD

• 实测条带：
• 57kD

• 背景：
• CK4 is a cytokeratin with a molecular weight of 59 kDa. It is a member of type II cytokeratin family. CK4 is widely expressed in non keratinocytes and stratified squamous epithelium. It is mainly used to label esophageal and oral squamous epithelial cells and tumors of their origin.

• 功能：
• disease:Defects in KRT4 are a cause of white sponge nevus of cannon (WSN) [MIM:193900]. WSN is a rare autosomal dominant disorder which predominantly affects non-cornified stratified squamous epithelia. Clinically, it is characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,polymorphism:Three alleles of K4 are known: K4A2 (shown here), K4A1 and K4B.,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins. Ke

• 细胞定位：
• Cytoplasmic, Membranous

• 组织表达：
• Detected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth and lingual mucosa, and in cells and cell clusters in the mucosa and serous gland ducts of the esophageal submucosa (at protein level). Expressed widely in the exocervix and esophageal epithelium, with lowest levels detected in the basal cell layer.

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