PSMD11 (PTR1354) mouse mAb
- 货号：YM4769
- 应用：WB;IF;ELISA
- 种属：Human;Mouse;Rat;
- 简介：
- >>Proteasome;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Spinocerebellar ataxia;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Epstein-Barr virus infection
- 蛋白名称：
- 26S proteasome non-ATPase regulatory subunit 11
- 免疫原：
- Synthesized peptide derived from human protein.AA range:250-350
- 特异性：
- This antibody detects endogenous levels of PSMD11.
- 组成：
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
- 来源：
- Mouse, Monoclonal/IgG3, kappa
- 稀释：
- WB 1:500-2000. IF 1:100-500. ELISA 1:1000-5000
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- PSMD11;26S proteasome non-ATPase regulatory subunit 11;26S proteasome regulatory subunit RPN6;26S proteasome regulatory subunit S9;26S proteasome regulatory subunit p44.5
- 背景：
- The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq,
- 功能：
- function:Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.,similarity:Belongs to the proteasome subunit S9 family.,similarity:Contains 1 PCI domain.,subunit:Component of the PA700 complex.,
- 组织表达：
- Highly expressed in embryonic stem cells (ESCs). Expression decreases as ESCs differentiate.
- Various whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with anti-PSMD11 (PTR1354) antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody.
Lane 1: MCF7
Lane 2: HepG2
Lane 3: LN18
Lane 4: U2OS
