CRHR2 (PTR1205) mouse mAb
- 货号：YM4731
- 应用：WB;IF;ELISA
- 种属：Human;Mouse;Rat;
- 蛋白名称：
- Corticotropin-releasing factor receptor 2 (CRF-R-2) (CRF-R2) (CRFR-2) (Corticotropin-releasing hormone receptor 2) (CRH-R-2) (CRH-R2)
- 免疫原：
- Synthesized peptide derived from human CRHR2 AA range: 50-150
- 特异性：
- This antibody detects endogenous levels of CRHR2 protein.
- 组成：
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
- 来源：
- Mouse, Monoclonal/IgG2b, kappa
- 稀释：
- WB 1:500-2000. IF 1:100-500. ELISA 1:1000-5000
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 背景：
- corticotropin releasing hormone receptor 2(CRHR2) Homo sapiens The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011],
- 功能：
- G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
- Whole cell lysates were separated by 12% SDS-PAGE, and the membrane was blotted with anti-CRHR2 (PTR1319) antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody.
Lane 1: Neuro-2a
