• 靶点：
• IL-1β

• 简介：
• >>Antifolate resistance;>>MAPK signaling pathway;>>Cytokine-cytokine receptor interaction;>>NF-kappa B signaling pathway;>>Necroptosis;>>Osteoclast differentiation;>>Toll-like receptor signaling pathway;>>NOD-like receptor signaling pathway;>>Cytosolic DNA-sensing pathway;>>C-type lectin receptor signaling pathway;>>Hematopoietic cell lineage;>>IL-17 signaling pathway;>>Th17 cell differentiation;>>TNF signaling pathway;>>Inflammatory mediator regulation of TRP channels;>>Non-alcoholic fatty liver disease;>>AGE-RAGE signaling pathway in diabetic complications;>>Alcoholic liver disease;>>Type I diabetes mellitus;>>Alzheimer disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Pathogenic Escherichia coli infection;>>Shigellosis;>>Salmonella infection;>>Pertussis;>>Legionellosis;>>Yersinia infection;>>Leishmaniasis;>>Chagas disease;>>African trypanosomiasis;>>Malaria;>>Amoebiasis;>>Tuberculosis;>>Measles;>>Human cytomegalovirus infection;>>Influenza A;>>Herpes simp

• 基因名称：
• IL1B IL1F2

• 蛋白名称：
• Interleukin-1 beta (IL-1 beta) (Catabolin)

• Human Gene Id：
• 3553

• Human Swiss Prot No：
• P01584

• Mouse Gene Id：
• 16176

• Mouse Swiss Prot No：
• P10749

• Rat Swiss Prot No：
• Q63264

• 免疫原：
• Synthesized peptide derived from human IL-1β AA range: 150-250

• 特异性：
• This antibody detects endogenous levels of IL-1β protein.

• 组成：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• 来源：
• Mouse, Monoclonal/IgG1, kappa

• 稀释：
• WB 1:500-2000. IF 1:100-500. ELISA 1:1000-5000

• 纯化工艺：
• Protein G

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Interleukin-1 beta (IL-1 beta) (Catabolin)

• 分子量：
• 31kD

• 实测条带：
• 31kD,18kD

• 背景：
• interleukin 1 beta(IL1B) Homo sapiens The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008],

• 功能：
• domain:The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.,function:Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.,online information:Interleukin-1 entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the IL-1 family.,subcellular location:The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.,subunit:Mono

• 细胞定位：
• 0

• 组织表达：
• Expressed in activated monocytes/macrophages (at protein level).

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