SOX-2 (PTR1367) mouse mAb
- 货号：YM4472
- 应用：WB;IF;ELISA
- 种属：Human;Mouse;
- 简介：
- >>Hippo signaling pathway;>>Signaling pathways regulating pluripotency of stem cells
- 蛋白名称：
- Transcription factor SOX-2
- 特异性：
- This antibody detects endogenous levels of SOX-2 protein.
- 组成：
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
- 来源：
- Mouse, Monoclonal/IgG1,kappa
- 稀释：
- WB 1:500-2000.IF 1:100-500.ELISA 1:1000-5000.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- SOX2;Transcription factor SOX-2
- 背景：
- SRY-box 2(SOX2) Homo sapiens This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008],
- 功能：
- disease:Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.,function:Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.,online information:Sox2 entry,PTM:Sumoylation inhibits bin
- 组织表达：
- Fetal brain,Lung,Retina,
- Whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with anti-SOX-2 (PTR1367) antibody. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody.
Lane 1: NCCIT
Predicted band size: 34kDa
Observed band size: 34kDa
