- 靶点：
- Collagen II
- 简介：
- >>PI3K-Akt signaling pathway;>>Focal adhesion;>>ECM-receptor interaction;>>Protein digestion and absorption;>>Human papillomavirus infection
- 基因名称：
- COL2A1
- 蛋白名称：
- Collagen alpha-1(II) chain (Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain; Chondrocalcin]
- Human Gene Id：
- 1280
- Human Swiss Prot No：
- P02458
- Mouse Swiss Prot No：
- P28481
- Rat Swiss Prot No：
- P05539
- 免疫原：
- Synthetic Peptide of Collagen II
- 特异性：
- The antibody detects endogenous Collagen II protein
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Monoclonal, Mouse
- 稀释：
- IHC 1:50-300. IF 1:50-200
- 纯化工艺：
- The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
- 浓度：
- 1 mg/ml
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- Collagen alpha-1(II) chain (Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain;Chondrocalcin]
- 实测条带：
- 142kD
- 背景：
- This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. [provided by RefSeq, Jul 2008],
- 功能：
- disease:Defects in COL2A1 are a cause of primary avascular necrosis of femoral head (ANFH) [MIM:608805]; also called ischemic necrosis of the femoral head or osteonecrosis of the femoral head. ANFH causes disability that often requires surgical intervention. Most cases are sporadic, but families in which there is an autosomal dominant inheritance of the disease have been identified. It has been estimated that 300,000 to 600,000 people in the United States have ANFH. Approximately 15,000 new cases of this common and disabling disorder are reported annually. The age at the onset is earlier than that for osteoarthritis. The diagnosis is typically made when patients are between the ages of 30 and 60 years. The clinical manifestations, such as pain on exertion, a limping gait, and a discrepancy in leg length, cause considerable disability. Moreover, nearly 10 percent of the 500,000 total-hip
- 细胞定位：
- Secreted, extracellular space, extracellular matrix .
- 组织表达：
- Isoform 2 is highly expressed in juvenile chondrocyte and low in fetal chondrocyte.
TAK-715 alleviated IL-1β-induced apoptosis and ECM degradation in nucleus pulposus cells and attenuated intervertebral disc degeneration ex vivo and in vivo ARTHRITIS RESEARCH & THERAPY Lin Huang IHC Rat disc samples
货号：YM3793
The regulatory role and mechanism of lncTUG1 on cartilage apoptosis and inflammation in osteoarthritis. Xiao-Yu Chen WB,ICC,IF Human 1:1000 C28/I2 cell
货号：YM3793
Geometric constraint-triggered collagen expression mediates bacterial-host adhesion Nature Communications Feng Yuting IF Rat 1:50 IEC-6 cell
货号：YM3793
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- Antibody-FAQs
- 产品图片
- Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
