• 靶点：
• Collagen IV

• 简介：
• >>PI3K-Akt signaling pathway;>>Focal adhesion;>>ECM-receptor interaction;>>Relaxin signaling pathway;>>AGE-RAGE signaling pathway in diabetic complications;>>Protein digestion and absorption;>>Amoebiasis;>>Human papillomavirus infection;>>Pathways in cancer;>>Small cell lung cancer

• 基因名称：
• COL4A1

• 蛋白名称：
• Collagen alpha-1(IV) chain [Cleaved into: Arresten]

• Human Gene Id：
• 1282

• Human Swiss Prot No：
• p02462

• Mouse Swiss Prot No：
• P02463

• 免疫原：
• Synthesized peptide derived from human Collagen Type IV AA range: 1600-1669

• 特异性：
• The antibody detects endogenous Collagen IV protein

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• IF 1:50-200 IHC 1:50-300

• 纯化工艺：
• The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Collagen alpha-1(IV) chain [Cleaved into: Arresten]

• 实测条带：
• 161kD

• 背景：
• This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],

• 功能：
• disease:Defects in COL4A1 are a cause of brain small vessel disease with hemorrhage [MIM:607595]. Brain small vessel diseases underlie 20 to 30 percent of ischemic strokes and a larger proportion of intracerebral hemorrhages. Inheritance is autosomal dominant.,disease:Defects in COL4A1 are a cause of porencephaly type 1 [MIM:175780]; also known as encephaloclastic porencephaly. Porencephaly is a term used for any cavitation or cerebrospinal fluid-filled cyst in the brain. Porencephaly type 1 is usually unilateral and results from focal destructive lesions such as fetal vascular occlusion or birth trauma. Inheritance is autosomal dominant.,disease:Defects in COL4A1 are the cause of hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC) [MIM:611773]. The clinical renal manifestations include hematuria and bilateral large cysts. Histologic analysis revealed complex bas

• 细胞定位：
• Secreted, extracellular space, extracellular matrix, basement membrane .

• 组织表达：
• Highly expressed in placenta.

Cirrhotic Hepatocellular Carcinoma-Based Decellularized Liver Cancer Model for Local Chemoembolization Evaluation Acta Biomaterialia Meijuan Wang IF Rat 1:200 liver tissue
货号：YM3756

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