• 靶点：
• COX IV

• 简介：
• >>Oxidative phosphorylation;>>Metabolic pathways;>>Cardiac muscle contraction;>>Thermogenesis;>>Non-alcoholic fatty liver disease;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Chemical carcinogenesis - reactive oxygen species;>>Diabetic cardiomyopathy

• 基因名称：
• COX4I1

• 蛋白名称：
• Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

• Human Gene Id：
• 1327

• Human Swiss Prot No：
• P13073

• Mouse Gene Id：
• 12857

• Mouse Swiss Prot No：
• P19783

• Rat Gene Id：
• 29445

• Rat Swiss Prot No：
• P10888

• 免疫原：
• Recombinant Protein of Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

• 特异性：
• The antibody detects endogenous COX IV protein.

• 组成：
• PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

• 来源：
• Monoclonal, Mouse

• 稀释：
• WB 1:1000-3000 IF 1:200 IHC 1:50-300

• 纯化工艺：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• COX4I1;COX4;Cytochrome c oxidase subunit 4 isoform 1, mitochondrial;Cytochrome c oxidase polypeptide IV;Cytochrome c oxidase subunit IV isoform 1;COX IV-1

• 实测条带：
• 15kD

• 背景：
• Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to this gene are located on chromosomes

• 功能：
• function:This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.,similarity:Belongs to the cytochrome c oxidase IV family.,tissue specificity:Ubiquitous.,

• 细胞定位：
• Mitochondrion inner membrane ; Single-pass membrane protein .

• 组织表达：
• Ubiquitous.

The nature compound dehydrocrenatidine exerts potent antihepatocellular carcinoma by destroying mitochondrial complexes in vitro and in vivo 2022 Feb 02. WB Human
货号：YM3033

Mutation of IDH1 aggravates the fatty acid‑induced oxidative stress in HCT116 cells by affecting the mitochondrial respiratory chain. Molecular Medicine Reports Mol Med Rep. 2019 Apr;19(4):2509-2518 WB Human 1:1000 HCT116 cell
货号：YM3033

Immunogenic Radiation Therapy for Enhanced Antitumor Immunity via a Core–Shell Nanosensitizer-Mediated Immunosuppressive Tumor Microenvironment Modulation. ACS Nano Jin-Xiang Chen IF Mouse 4T1 cell-xenograft
货号：YM3033

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