• 靶点：
• GRAP2

• 简介：
• >>T cell receptor signaling pathway

• 基因名称：
• grap2

• Human Gene Id：
• 9402

• Human Swiss Prot No：
• O75791

• Mouse Swiss Prot No：
• O89100

• 免疫原：
• Recombinant protein of human GRAP2.

• 特异性：
• This antibody detects endogenous levels of GRAP2 and does not cross-react with related proteins.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• wb dilution 1:1000

• 纯化工艺：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Adapter protein GRID;GADS;GADS protein;GRAP-2;Grap2;GRAP2_HUMAN;GRB-2-like protein;GRB2-related adapter protein 2;GRB2-related adaptor protein 2;GRB2-related protein with insert domain;GRB2L;GRBLG;GRBX;Grf-40;Grf40 adapter protein;Grf40;GRID;Growth factor receptor-binding protein;Growth factor receptor-bound protein 2-related adaptor protein 2;GRPL;Hema;Hematopoietic cell-associated adapter protein GrpL;Hematopoietic cell-associated adaptor protein GRPL;Mona;p38;Protein GADS;SH3-SH2-SH3 adapter Mona;SH3-SH2-SH3 adaptor molecule.

• 实测条带：
• 38kD

• 背景：
• This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014],

• 功能：
• function:Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.,similarity:Belongs to the GRB2/sem-5/DRK family.,similarity:Contains 1 SH2 domain.,similarity:Contains 2 SH3 domains.,subunit:Interacts with phosphorylated LIME1 upon TCR activation (By similarity). Interacts with phosphorylated LAT and LAX1 upon TCR activation. Interacts with SHB.,

• 细胞定位：
• Nucleus . Cytoplasm . Endosome .

• 组织表达：
• Blood,Lung,Platelet,Spleen,T-cell,Thymus,

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