• 靶点：
• E2F-1

• 简介：
• >>Endocrine resistance;>>Cell cycle;>>Mitophagy - animal;>>Cellular senescence;>>Cushing syndrome;>>Hepatitis C;>>Hepatitis B;>>Human cytomegalovirus infection;>>Human papillomavirus infection;>>Human T-cell leukemia virus 1 infection;>>Kaposi sarcoma-associated herpesvirus infection;>>Epstein-Barr virus infection;>>Pathways in cancer;>>MicroRNAs in cancer;>>Chemical carcinogenesis - receptor activation;>>Pancreatic cancer;>>Glioma;>>Prostate cancer;>>Melanoma;>>Bladder cancer;>>Chronic myeloid leukemia;>>Small cell lung cancer;>>Non-small cell lung cancer;>>Breast cancer;>>Hepatocellular carcinoma;>>Gastric cancer

• 基因名称：
• e2f1

• Human Gene Id：
• 1869

• Human Swiss Prot No：
• Q01094

• Mouse Swiss Prot No：
• Q61501

• 免疫原：
• Purified recombinant human E2F-1 protein fragments expressed in E.coli.

• 特异性：
• This antibody detects endogenous levels of E2F-1 and does not cross-react with related proteins.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• wb dilution 1:500 icc dilution 1:100. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Dmel\CG6376；Dmel_CG6376；drosE2F1；E(Sev-CycE)3A；E(var)3-93E；E2-promoter binding facto；E2F 1；E2F transcription factor 1；E2F-1；E2f-PA；E2f-PB；E2f-PC；E2F1；E2f1 E2F transcription factor 1；E2F1_HUMAN；Evar(3)164；KIAA4009；l(3)07172；l(3)j3B1；l(3)j3C2；l(3)rM729；mKIAA4009；OTTHUMP00000030661；PBR3；PRB binding protein E2F 1；PRB-binding protein E2F-1；RBAP 1；RBAP-1；RBAP1；RBBP-3；RBBP3；RBP 3；RBP3；Retinoblastoma-associated protein 1；Retinoblastoma-binding protein 3；Transcription factor E2F1.

• 实测条带：
• 60kD

• 背景：
• The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can media

• 功能：
• function:Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis.,PTM:Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase.,similarity:Belongs to the E2F/DP family.,subunit:Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The E2F-1 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle, RB1 becomes phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, ren

• 细胞定位：
• Nucleus .

• 组织表达：
• Brain,Epithelium,Pancreas,Skin,

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