• 靶点：
• JNK1

• 简介：
• >>Endocrine resistance;>>MAPK signaling pathway;>>ErbB signaling pathway;>>Ras signaling pathway;>>cAMP signaling pathway;>>FoxO signaling pathway;>>Sphingolipid signaling pathway;>>Mitophagy - animal;>>Autophagy - animal;>>Protein processing in endoplasmic reticulum;>>Apoptosis;>>Apoptosis - multiple species;>>Necroptosis;>>Wnt signaling pathway;>>Osteoclast differentiation;>>Focal adhesion;>>Tight junction;>>Toll-like receptor signaling pathway;>>NOD-like receptor signaling pathway;>>RIG-I-like receptor signaling pathway;>>C-type lectin receptor signaling pathway;>>IL-17 signaling pathway;>>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>T cell receptor signaling pathway;>>Fc epsilon RI signaling pathway;>>TNF signaling pathway;>>Neurotrophin signaling pathway;>>Retrograde endocannabinoid signaling;>>Dopaminergic synapse;>>Inflammatory mediator regulation of TRP channels;>>Insulin signaling pathway;>>GnRH signaling pathway;>>Progesterone-mediated oocyte maturation;>>Pr

• 基因名称：
• mapk8

• Human Gene Id：
• 5599

• Human Swiss Prot No：
• P45983

• Mouse Swiss Prot No：
• Q91Y86

• 免疫原：
• Purified recombinant human JNK1 protein fragments expressed in E.coli.

• 特异性：
• This antibody detects endogenous levels of JNK1 and does not cross-react with related proteins.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• wb dilution 1:1000 icc dilution 1:100. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• AI849689；c Jun N terminal kinase 1；C-JUN kinase 1；c-Jun N-terminal kinase 1；EC 2.7.11.24；JAK 1A；JAK1A；JNK 1；JNK 46；JNK；JNK-46；JNK1A2；JNK21B1/2；MAP kinase 8；MAPK 8；MAPK8；Mitogen activated protein kinase 8；Mitogen-activated protein kinase 8；MK08_HUMAN；p54 gamma；PRKM 8；PRKM8；Protein kinase JNK1；Protein kinase, mitogen-activated, 8；SAPK 1；SAPK gamma；SAPK1；Stress activated protein kinase JNK1；Stress-activated protein kinase 1；Stress-activated protein kinase JNK1；Tyrosine protein kinase JAK1 .

• 实测条带：
• 46,54kD

• 背景：
• The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spl

• 功能：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.,enzyme regulation:Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. Inhibited by dual specificity phosphatases, such as DUSP1.,function:JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.,function:Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP

• 细胞定位：
• Cytoplasm . Nucleus . Cell junction, synapse . In the cortical neurons, predominantly cytoplasmic and associated with the Golgi apparatus and endosomal fraction. Increased neuronal activity increases phosphorylated form at synapses (By similarity). Colocalizes with POU5F1 in the nucleus. .

• 组织表达：
• Brain,Epithelium,Fetal brain,Lung,Pooled,Testis,

Fusaric acid inhibits proliferation and induces apoptosis through triggering endoplasmic reticulum stress in MCF-7 human breast cancer cells. Yao Xiaoqiang WB Human 1:1000 MCF-7 cell
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