Hsp90 mouse mAb

    • 货号:YM1398
    • 应用:WB
    • 种属:Human;Mouse;Rat
      • 靶点:
      • HSP 90
      • 简介:
      • >>Protein processing in endoplasmic reticulum;>>PI3K-Akt signaling pathway;>>Necroptosis;>>Antigen processing and presentation;>>NOD-like receptor signaling pathway;>>IL-17 signaling pathway;>>Th17 cell differentiation;>>Progesterone-mediated oocyte maturation;>>Estrogen signaling pathway;>>Salmonella infection;>>Pathways in cancer;>>Chemical carcinogenesis - receptor activation;>>Prostate cancer;>>Lipid and atherosclerosis;>>Fluid shear stress and atherosclerosis
      • 基因名称:
      • hsp90
      • Human Gene Id:
      • 3320
      • Human Swiss Prot No:
      • P07900
      • Mouse Swiss Prot No:
      • P07901
      • 免疫原:
      • Purified recombinant human HSP90AA1 protein fragments expressed in E.coli
      • 特异性:
      • This antibody detects endogenous levels of Hsp90 alpha and Hsp90 beta.
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Monoclonal, Mouse
      • 稀释:
      • wb dilution 1:2000
      • 纯化工艺:
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称:
      • D6S182;FLJ26984;FLJ31884;Heat shock 86 kDa;heat shock 90kDa protein 1 alpha;Heat shock protein 90kDa alpha cytosolic class A member 1;Heat shock protein 90kDa alpha cytosolic class B member 1;Heat shock protein HSP 90 alpha;Heat shock protein HSP 90 beta;Heat shock protein HSP 90-alpha;HS90A_HUMAN;HSP 84;HSP 86;Hsp 90;HSP84;HSP86;Hsp89;Hsp90;HSP90 Beta;HSP90A;HSP90AA1;HSP90AB1;HSP90B;HSP90N;HSPC1;HSPC2;HSPCA;HSPCAL1;HSPCAL4;HSPCB;HSPN;LAP2;Lipopolysaccharide associated protein2;LPS associated protein 2;NY REN 38 antigen;Renal carcinoma antigen NY-REN-38.
      • 实测条带:
      • 90kD
      • 背景:
      • The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
      • 功能:
      • caution:Despite classification as a pseudogene, the existence of this protein is supported by unambiguous mass spectrometry evidence.,function:Molecular chaperone.,function:Molecular chaperone. Has ATPase activity.,similarity:Belongs to the heat shock protein 90 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Interacts with AHSA1, SMYD3 and TOM34. Interacts with FNIP1 and HSF1.,
      • 细胞定位:
      • Nucleus . Cytoplasm . Melanosome . Cell membrane . Mitochondrion . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
      • 组织表达:
      • Adult brain,Brain,Brain cortex,Breast,Cajal-Retzius

      HSP90 inhibitor AUY922 can reverse Fulvestrant induced feedback reaction in human breast cancer cells. CANCER SCIENCE 2017 May 19 WB Human MCF-7 cell,T47D cell
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      Mangiferin improves hepatic damage-associated molecular patterns, lipid metabolic disorder and mitochondrial dysfunction in alcohol hepatitis rats. Food & Function Food Funct. 2019 Jun;10(6):3514-3534 IHC Rat Liver, kidney , spleen
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      • 产品图片
      • Western blot detection of Hsp90 in Hela,3T3,C6,K562 and A549 cell lysates using Hsp90 mouse mAb (1:2000 diluted).Exposion time: 4min.Predicted band size:90KDa.Observed band size:90KDa.