• 靶点：
• PLAP

• 简介：
• >>Thiamine metabolism;>>Folate biosynthesis;>>Metabolic pathways;>>Biosynthesis of cofactors

• 基因名称：
• alpp

• Human Gene Id：
• 250

• Human Swiss Prot No：
• P05187

• 免疫原：
• Purified recombinant Placental alkaline phosphatase (PLAP) protein fragments expressed in E.coli.

• 特异性：
• This antibody detects endogenous levels of Placental alkaline phosphatase (PLAP) and does not cross-react with related proteins.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• wb 1:1000

• 纯化工艺：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Alkaline phosphatase;Alkaline phosphatase placental;Alkaline phosphatase placental type;Alkaline phosphatase Regan isozyme;ALP;Alp1;ALPP;FLJ61142;Germ-cell alkaline phosphatase;nagao isozyme;OTTHUMP00000164354;PALP;Placental alkaline phosphatase 1;placental heat-stable alkaline phosphatase;placental type;PLAP;PLAP-1;PLAP1;PPB1_HUMAN.

• 实测条带：
• 70kD

• 背景：
• The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015],

• 功能：
• catalytic activity:A phosphate monoester + H(2)O = an alcohol + phosphate.,cofactor:Binds 1 magnesium ion.,cofactor:Binds 2 zinc ions.,miscellaneous:In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).,online information:Alkaline phosphatase entry,polymorphism:Placental ALP is highly polymorphic, there are at least three common alleles.,similarity:Belongs to the alkaline phosphatase family.,subunit:Homodimer.,

• 细胞定位：
• Cell membrane; Lipid-anchor, GPI-anchor .

• 组织表达：
• Detected in placenta (at protein level).

Placenta-derived exosomal miR-135a-5p promotes gestational diabetes mellitus pathogenesis by activating PI3K/AKT signalling pathway via SIRT1. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Jianying Yan WB Human plasma
货号：YM1349

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