• 靶点：
• CYP7A1

• 简介：
• >>Primary bile acid biosynthesis;>>Steroid hormone biosynthesis;>>Metabolic pathways;>>PPAR signaling pathway;>>Bile secretion;>>Cholesterol metabolism

• 基因名称：
• CYP7A1

• 蛋白名称：
• Cholesterol 7-alpha-monooxygenase

• Human Gene Id：
• 1581

• Human Swiss Prot No：
• P22680

• Mouse Swiss Prot No：
• Q64505

• 免疫原：
• Purified recombinant human CYP7A1 (C-terminus) protein fragments expressed in E.coli.

• 特异性：
• CYP7A1 Monoclonal Antibody detects endogenous levels of CYP7A1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• WB 1:1000 - 1:2000. Not yet tested in other applications.

• 纯化工艺：
• Affinity purification

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CYP7A1;CYP7;Cholesterol 7-alpha-monooxygenase;CYPVII;Cholesterol 7-alpha-hydroxylase;Cytochrome P450 7A1

• 分子量：
• 58kD

• 背景：
• This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010],

• 功能：
• catalytic activity:Cholesterol + NADPH + O(2) = 7-alpha-hydroxycholesterol + NADP(+) + H(2)O.,cofactor:Heme group.,online information:Cholesterol-7 alpha-hydroxylase entry,pathway:Lipid metabolism; bile acid biosynthesis.,similarity:Belongs to the cytochrome P450 family.,

• 细胞定位：
• Endoplasmic reticulum membrane ; Single-pass membrane protein . Microsome membrane ; Single-pass membrane protein .

• 组织表达：
• Detected in liver.

Investigation of the Lipid-Lowering Mechanisms and Active Ingredients of Danhe Granule on Hyperlipidemia Based on Systems Pharmacology. Frontiers in Pharmacology Front Pharmacol. 2020 May;0:528 WB Golden hamster 1:1000 Liver
货号：YM1026

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