- 靶点：
- WIF-1
- 简介：
- >>Wnt signaling pathway
- 基因名称：
- WIF1
- 蛋白名称：
- Wnt inhibitory factor 1
- Human Gene Id：
- 11197
- Human Swiss Prot No：
- Q9Y5W5
- Mouse Swiss Prot No：
- Q9WUA1
- 免疫原：
- Purified recombinant fragment of human WIF-1 expressed in E. Coli.
- 特异性：
- WIF-1 Monoclonal Antibody detects endogenous levels of WIF-1 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Monoclonal, Mouse
- 稀释：
- WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
- 纯化工艺：
- Affinity purification
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- WIF1;Wnt inhibitory factor 1;WIF-1
- 分子量：
- 42kD
- 背景：
- The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010],
- 功能：
- function:Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.,similarity:Contains 1 WIF domain.,similarity:Contains 5 EGF-like domains.,
- 细胞定位：
- Secreted.
- 组织表达：
- Brain,
Single-Cell RNA Sequencing Reveals the Cellular Origin and Evolution of Breast Cancer in BRCA1 Mutation CarriersThe Cell Origin of BRCA1-Mutated Breast Cancer. CANCER RESEARCH Cancer Res. 2021 May;81(10):2600-2611 IHC Human normal breast tissues
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- Antibody-FAQs
- 产品图片
- Western Blot analysis using WIF-1 Monoclonal Antibody against HeLa (1), NIH/3T3 (2) and NTERA-2 (3) cell lysate.
- Immunohistochemistry analysis of paraffin-embedded ovary tumour tissues (left) and lung cancer (right) with DAB staining using WIF-1 Monoclonal Antibody.
- Immunofluorescence analysis of Hela cells using WIF-1 Monoclonal Antibody (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
