• 靶点：
• R-Spondin

• 简介：
• >>Wnt signaling pathway

• 基因名称：
• RSPO1

• 蛋白名称：
• R-spondin-1

• Human Gene Id：
• 284654

• Human Swiss Prot No：
• Q2MKA7

• Mouse Swiss Prot No：
• Q9Z132

• 免疫原：
• Purified recombinant fragment of R-spondin1 expressed in E. Coli.

• 特异性：
• R-Spondin Monoclonal Antibody detects endogenous levels of R-Spondin protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• Affinity purification

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• RSPO1;R-spondin-1;Roof plate-specific spondin-1;hRspo1

• 分子量：
• 29kD

• 背景：
• This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014],

• 功能：
• disease:Defects in RSPO1 are the cause of palmoplantar keratoderma with squamous cell carcinoma of skin and sex reversal (PKKSCC) [MIM:610644]. This recessive syndrome is characterized by XX (female to male) SRY-independent sex reversal, palmoplantar hyperkeratosis and predisposition to squamous cell carcinoma of the skin.,domain:The FU repeats are required for activation and stabilization of beta-catenin.,function:Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.,miscellaneous

• 细胞定位：
• Secreted . Nucleus . Seems to mainly localize to nucleoli. .

• 组织表达：
• Abundantly expressed in adrenal glands, ovary, testis, thyroid and trachea but not in bone marrow, spinal cord, stomach, leukocytes colon, small intestine, prostate, thymus and spleen.

Identification and Validation of Immune Implication of R-Spondin 1 and an R-Spondin 1-Related Prognostic Signature in Esophagus Cancer International Journal of Genomics Yuansheng Lin WB Human 1:1000 HEEC cell,EC109 cell,TE12 cell
货号：YM0566

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