• 靶点：
• Rictor

• 简介：
• >>mTOR signaling pathway

• 基因名称：
• RICTOR

• 蛋白名称：
• Rapamycin-insensitive companion of mTOR

• Human Gene Id：
• 253260

• Human Swiss Prot No：
• Q6R327

• Mouse Gene Id：
• 78757

• Mouse Swiss Prot No：
• Q6QI06

• 免疫原：
• Purified recombinant fragment of human Rictor expressed in E. Coli.

• 特异性：
• Rictor Monoclonal Antibody detects endogenous levels of Rictor protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• Affinity purification

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• RICTOR;KIAA1999;Rapamycin-insensitive companion of mTOR;AVO3 homolog;hAVO3

• 分子量：
• 192kD

• 背景：
• RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008],

• 功能：
• function:Plays an essential role in embryonic growth and development (By similarity). Part of the TORC2 complex which plays a critical role in AKT1 'Ser-473' phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.,similarity:Belongs to the pianissimo family.,subunit:Forms part of the target of rapamycin 2 complex (TORC2) comprised of FRAP1, LST8, PROTOR1, RICTOR and MAPKAP1. TORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to FRAP1 and PROTOR1 within the TORC2 complex. May interact with PROTOR2.,

• 细胞定位：
• cytosol,TORC2 complex,

• 组织表达：
• Amygdala,Brain,Epithelium,Lymph,

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