• 靶点：
• Msi1

• 简介：
• >>mRNA surveillance pathway

• 基因名称：
• MSI1

• 蛋白名称：
• RNA-binding protein Musashi homolog 1

• Human Gene Id：
• 4440

• Human Swiss Prot No：
• O43347

• Mouse Swiss Prot No：
• Q61474

• 免疫原：
• Purified recombinant fragment of human Msi1 expressed in E. Coli.

• 特异性：
• Msi1 Monoclonal Antibody detects endogenous levels of Msi1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• WB 1:500 - 1:2000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• Affinity purification

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• MSI1;RNA-binding protein Musashi homolog 1;Musashi-1

• 分子量：
• 39kD

• 背景：
• This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008],

• 功能：
• domain:The first RNA recognition motif binds more strongly to RNA compared to the second one.,function:RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system.,similarity:Belongs to the Musashi family.,similarity:Contains 2 RRM (RNA recognition motif) domains.,tissue specificity:Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines.,

• 细胞定位：
• Cytoplasm . Nucleus .

• 组织表达：
• Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines.

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