IGFBP2 Monoclonal Antibody
- 货号：YM0355
- 应用：WB;IHC;IF;ELISA
- 种属：Human
- 蛋白名称：
- Insulin-like growth factor-binding protein 2
- 免疫原：
- Purified recombinant fragment of protein IGFBP2 (aa180-328) expressed in E. Coli.
- 特异性：
- IGFBP2 Monoclonal Antibody detects endogenous levels of IGFBP2 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 稀释：
- WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
- 纯化工艺：
- Affinity purification
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- IGFBP2;BP2;IBP2;Insulin-like growth factor-binding protein 2;IBP-2;IGF-binding protein 2;IGFBP-2
- 背景：
- The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015],
- 功能：
- function:IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.,PTM:O-glycosylated.,similarity:Contains 1 IGFBP N-terminal domain.,similarity:Contains 1 thyroglobulin type-1 domain.,subunit:Binds IGF2 more than IGF1.,
- 组织表达：
- Brain,Cerebrospinal fluid,Fetal liver,Ovary,Placenta,Retina
- Western Blot analysis using IGFBP2 Monoclonal Antibody against truncated IGFBP2-His recombinant protein (1) and truncated IGFBP2 (aa40-328)-hIgGFc transfected CHO-K1 cell lysate (2).
- Immunohistochemistry analysis of paraffin-embedded human lung cancer (A), recturn(B), prostate (C), colon cancer (D) showing cytoplasmic localization with DAB staining using IGFBP2 Monoclonal Antibody.
