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CD86 Monoclonal Antibody

货号：YM0137
应用：WB;ELISA
种属：Human

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靶点：
CD86

简介：
>>Cell adhesion molecules;>>Toll-like receptor signaling pathway;>>Intestinal immune network for IgA production;>>Type I diabetes mellitus;>>Kaposi sarcoma-associated herpesvirus infection;>>Transcriptional misregulation in cancer;>>Autoimmune thyroid disease;>>Systemic lupus erythematosus;>>Rheumatoid arthritis;>>Allograft rejection;>>Graft-versus-host disease;>>Viral myocarditis

基因名称：
CD86

蛋白名称：
T-lymphocyte activation antigen CD86

Human Gene Id：
942

Human Swiss Prot No：
P42081

Mouse Swiss Prot No：
P42082

免疫原：
Purified recombinant fragment of human CD86 expressed in E. Coli.

特异性：
CD86 Monoclonal Antibody detects endogenous levels of CD86 protein.

组成：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

来源：
Monoclonal, Mouse

稀释：
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

纯化工艺：
Affinity purification

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

其他名称：
CD86;CD28LG2;T-lymphocyte activation antigen CD86;Activation B7-2 antigen;B70;BU63;CTLA-4 counter-receptor B7.2;FUN-1;CD antigen CD86

分子量：
60-80kD

背景：
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011],

功能：
function:Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.,online information:CD86 entry,PTM:Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with MARCH8. Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with adenovirus subgroup B fiber proteins and acts as

细胞定位：
Cell membrane; Single-pass type I membrane protein.

组织表达：
Expressed by activated B-lymphocytes and monocytes.

Ciprofloxacin promotes polarization of CD86+CD206‑ macrophages to suppress liver cancer. ONCOLOGY REPORTS Oncol Rep. 2020 Jul;44(1):91-102 WB Human 1:1000 HepG2 cell
货号：YM0137

Fan, Mengtian, et al. "Ciprofloxacin promotes polarization of CD86+ CD206‑macrophages to suppress liver cancer." Oncology reports 44.1 (2020): 91-102.
货号：YM0137