• 靶点：
• CD38

• 简介：
• >>Nicotinate and nicotinamide metabolism;>>Metabolic pathways;>>Calcium signaling pathway;>>Hematopoietic cell lineage;>>Oxytocin signaling pathway;>>Salivary secretion;>>Pancreatic secretion

• 基因名称：
• CD38

• 蛋白名称：
• ADP-ribosyl cyclase 1

• Human Gene Id：
• 952

• Human Swiss Prot No：
• P28907

• Mouse Swiss Prot No：
• P56528

• 免疫原：
• Purified recombinant fragment of human CD38 expressed in E. Coli.

• 特异性：
• CD38 Monoclonal Antibody detects endogenous levels of CD38 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• Affinity purification

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CD38;ADP-ribosyl cyclase 1;Cyclic ADP-ribose hydrolase 1;cADPr hydrolase 1;T10;CD antigen CD38

• 分子量：
• 34kD

• 背景：
• The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],

• 功能：
• catalytic activity:NAD(+) + H(2)O = ADP-ribose + nicotinamide.,developmental stage:Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.,enzyme regulation:ATP inhibits the hydrolyzing activity.,function:Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.,online information:CD38 entry,similarity:Belongs to the ADP-ribosyl cyclase family.,tissue specificity:Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.,

• 细胞定位：
• Membrane; Single-pass type II membrane protein.

• 组织表达：
• Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.

CD38 affects the biological behavior and energy metabolism of nasopharyngeal carcinoma cells. INTERNATIONAL JOURNAL OF ONCOLOGY Int J Oncol. 2019 Feb;54(2):585-599 WB,IHC Human 1:1000,1:1000 NPC epithelial tissues 5-8F cell
货号：YM0122

CD38 enhances the proliferation and inhibits the apoptosis of cervical cancer cells by affecting the mitochondria functions. MOLECULAR CARCINOGENESIS Mol Carcinogen. 2017 Oct;56(10):2245-2257 WB Human,Mouse 1:1000 CaSki cell-xenograft,cervical cancer tissues CaSki cell， HeLa cell
货号：YM0122

CD38 is involved in cell energy metabolism via activating the PI3K/AKT/mTOR signaling pathway in cervical cancer cells. INTERNATIONAL JOURNAL OF ONCOLOGY Int J Oncol. 2020 Jul;57(1):338-354 WB Human 1:1000 CaSki cell，Hela cell
货号：YM0122

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