CD31 Monoclonal Antibody

    • 货号:YM0118
    • 应用:WB;IHC;IF;ELISA
    • 种属:Human;Rabbit
      • 靶点:
      • CD31
      • 简介:
      • >>Cell adhesion molecules;>>Leukocyte transendothelial migration;>>Malaria;>>Fluid shear stress and atherosclerosis
      • 基因名称:
      • PDGFRA
      • 蛋白名称:
      • Alpha-type platelet-derived growth factor receptor
      • Human Gene Id:
      • 5175
      • Human Swiss Prot No:
      • P16284
      • Mouse Swiss Prot No:
      • Q08481
      • 免疫原:
      • Purified recombinant fragment of human CD31 expressed in E. Coli.
      • 特异性:
      • CD31 Monoclonal Antibody detects endogenous levels of CD31 protein.
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Monoclonal, Mouse
      • 稀释:
      • WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
      • 纯化工艺:
      • Affinity purification
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称:
      • PECAM1;Platelet endothelial cell adhesion molecule;PECAM-1;EndoCAM;GPIIA';PECA1;CD antigen CD31
      • 分子量:
      • 83kD
      • 背景:
      • The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010],
      • 功能:
      • function:This protein is a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions.,online information:CD31 entry,online information:PECAM-1,online information:The Singapore human mutation and polymorphism database,PTM:Phosphorylated on Ser and Tyr residues after cellular activation.,similarity:Contains 6 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Long isoform predominates all tissues examined, isoform Delta12 was detected only in trachea and isoform Delta14-15 only in lung, isoform Delta14 was detected in all tissues examined with the strongest expression in heart.,
      • 细胞定位:
      • Cell membrane ; Single-pass type I membrane protein . Cell surface expression on neutrophils is down-regulated upon fMLP or CXCL8/IL8-mediated stimulation. .; [Isoform Long]: Cell membrane ; Single-pass type I membrane protein . Membrane raft . Cell junction . Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. .; [Isoform Delta15]: Cell junction . Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.
      • 组织表达:
      • Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells (PubMed:18388311, PubMed:21464369). Expressed in human umbilical vein endothelial cells (HUVECs) (at protein level) (PubMed:19342684, PubMed:17580308). Expressed on neutrophils (at protein level) (PubMed:17580308). Isoform Long predominates in all tissues examined (PubMed:12433657). Isoform Delta12 is detected only in trachea (PubMed:12433657). Isoform Delta14-15 is only detected in lung (PubMed:12433657). Isoform Delta14 is detected in all tissues examined with the strongest expression in heart (PubMed:12433657). Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleuk

      Enhanced antitumor effect on intrapulmonary tumors of docetaxel lung-targeted liposomes in a rabbit model of VX2 orthotopic lung cancer. Scientific Reports 2017 Aug 30 IHC Rabbit VX2 tumor
      货号:YM0118

      • 产品图片
      • Western Blot analysis using CD31 Monoclonal Antibody against truncated CD31 recombinant protein.
      • Immunohistochemistry analysis of paraffin-embedded human placenta tissues with AEC staining using CD31 Monoclonal Antibody.
      • Immunofluorescence analysis of paraffin-embedded human lung cancer(left) and breast cancer(right) cells using CD31 Monoclonal Antibody (green). Blue: DRAQ5 fluorescent DNA dye.