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Calnexin Monoclonal Antibody

货号：YM0089
应用：WB;IF;ELISA
种属：Human

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靶点：
Calnexin

简介：
>>Protein processing in endoplasmic reticulum;>>Phagosome;>>Antigen processing and presentation;>>Thyroid hormone synthesis;>>Human T-cell leukemia virus 1 infection

基因名称：
CANX

蛋白名称：
Calnexin

Human Gene Id：
821

Human Swiss Prot No：
P27824

Mouse Swiss Prot No：
P35564

免疫原：
Synthetic peptide corresponding to aa (CEAAEERPWLWVVYILTVAL) of human Calnexin, conjugated to KLH.

特异性：
Calnexin Monoclonal Antibody detects endogenous levels of Calnexin protein.

组成：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

来源：
Monoclonal, Mouse

稀释：
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

纯化工艺：
Affinity purification

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

其他名称：
CANX;Calnexin;IP90;Major histocompatibility complex class I antigen-binding protein p88;p90

分子量：
68kD

背景：
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008],

功能：
function:Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.,online information:Calnexin entry,similarity:Belongs to the calreticulin family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,

细胞定位：
Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Endoplasmic reticulum . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065). The palmitoylated form preferentially localizes to the perinuclear rough ER (PubMed:22314232). .

组织表达：
B-cell lymphoma,Epithelium,Fibroblast,Keratinocyte,Kidney,Liver,Lymph,Placenta,Platelet,

Identification of a Serum Exosome-Derived lncRNA‒miRNA‒mRNA ceRNA Network in Patients with Endometriosis Clinical and Experimental Obstetrics & Gynecology Yan Huang WB Human 1:1000 exosome
货号：YM0089