Cleaved-ITI-H2 (D702) Polyclonal Antibody
- 货号：YC0094
- 应用：WB;ELISA
- 种属：Human;Rat;Mouse;
- 蛋白名称：
- Inter-alpha-trypsin inhibitor heavy chain H2
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human ITIH2. AA range:653-702
- 特异性：
- Cleaved-ITI-H2 (D702) Polyclonal Antibody detects endogenous levels of fragment of activated ITI-H2 protein resulting from cleavage adjacent to D702.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- ITIH2;IGHEP2;Inter-alpha-trypsin inhibitor heavy chain H2;ITI heavy chain H2;ITI-HC2;Inter-alpha-inhibitor heavy chain 2;Inter-alpha-trypsin inhibitor complex component II;Serum-derived hyaluronan-associated protein;SHAP
- 背景：
- The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009],
- 功能：
- function:May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.,mass spectrometry: PubMed:9677337,PTM:Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.,similarity:Belongs to the ITIH family.,similarity:Contains 1 VWFA domain.,subunit:I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin.,
- Western Blot analysis of various cells using Cleaved-ITI-H2 (D702) Polyclonal Antibody
- Western blot analysis of ITIH2 (Cleaved-Asp702) Antibody. The lane on the right is blocked with the ITIH2 (Cleaved-Asp702) peptide.
