• 基因名称：
• CCL3

• 蛋白名称：
• C-C motif chemokine 3

• Human Gene Id：
• 6348

• Human Swiss Prot No：
• P10147

• Mouse Swiss Prot No：
• P10855

• 特异性：
• Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

• 储存：
• 2-8°C/6 months

• 其他名称：
• CCL3;G0S19-1;MIP1A;SCYA3;C-C motif chemokine 3;G0/G1 switch regulatory protein 19-1;Macrophage inflammatory protein 1-alpha;MIP-1-alpha;PAT 464.1;SIS-beta;Small-inducible cytokine A3;Tonsillar lymphocyte LD78 alpha protein

• 检测方法：
• Colorimetric

• 背景：
• function:Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).,induction:By TPA or PHA (TPA = 12-O-tetradecanoyl phorbol-13 acetate (tumor promoter); PHA = phytohemagglutinin (T-cell mitogen)).,online information:Macrophage inflammatory protein entry,PTM:N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T-cells.,similarity:Belongs to the intercrine beta (chemokine CC) family.,subunit:Self-associates. Also heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69).,

• 功能：
• cellular ion homeostasis, cellular calcium ion homeostasis, cellular metal ion homeostasis, exocytosis, cell motion,chemotaxis, defense response, inflammatory response, immune response, cytoskeleton organization, cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway, cell-cell signaling, behavior,locomotory behavior, response to wounding, vesicle-mediated transport, cellular homeostasis, cellular cation homeostasis, cellular di-, tri-valent inorganic cation homeostasis, secretion by cell, taxis, homeostatic process,regulation of viral genome replication, secretion, chemical homeostasis, regulation of viral reproduction, ion homeostasis, metal ion homeostasis, di-, tri-valent inorganic cation homeostasis, calcium ion homeostasis, cation homeostasis, cellular chemical homeostasis,

• 细胞定位：
• Secreted.

Alpha-Momorcharin Inhibits Proinflammatory Cytokine Expression by M1 Macrophages but Not Anti-Inflammatory Cytokine Expression by M2 Macrophages Journal of Inflammation Research Fubing Shen ELISA Human,Mouse
货号：KE1052

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