- 基因名称:
- IL33
- 蛋白名称:
- Interleukin-33
- Human Gene Id:
- 90865
- Human Swiss Prot No:
- O95760
- Mouse Swiss Prot No:
- Q8BVZ5
- 特异性:
- Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
- 储存:
- 2-8°C/6 months
- 其他名称:
- IL33;C9orf26;IL1F11;NFHEV;Interleukin-33;IL-33;Interleukin-1 family member 11;IL-1F11;Nuclear factor from high endothelial venules;NF-HEV
- 检测方法:
- Colorimetric
- 背景:
- caution:Was originally (PubMed:12819012) thought to one of the key factors that controls the specialized post-capillary high endothelial venules (HEV) phenotype found in organized secondary lymphoid tissue and to be nuclear localized.,function:Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T helper type 2-associated cytokines.,PTM:Proteolytically converted to a mature form by CASP1.,similarity:Belongs to the IL-1 family. Highly divergent.,tissue specificity:Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta.,
- 细胞定位:
- Nucleus . Chromosome . Cytoplasm . Cytoplasmic vesicle, secretory vesicle . Secreted . Associates with heterochromatin and mitotic chromosomes (PubMed:17185418). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). .
- 组织表达:
- Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta.
Relevance of serum interleukin-33 and ST2 levels and the natural course of chronic hepatitis B virus infection. BMC INFECTIOUS DISEASES 2016 May 16 ELISA Human Sera
货号:KE1038
Overexpression of serum sST2 is associated with poor prognosis in acute-on-chronic hepatitis B liver failure. Clinics and Research in Hepatology and Gastroenterology 2014 Nov 11 ELISA Human serum
货号:KE1038
Pan, Guoquan, et al. "Pro-inflammatory and Pro-apoptotic Role of IL-33 in the Human Acute Lung Injury (ALI) Development." Current Signal Transduction Therapy 10.1 (2015): 48-55.
货号:KE1038
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- 产品图片
- Pan, Guoquan, et al. "Pro-inflammatory and Pro-apoptotic Role of IL-33 in the Human Acute Lung Injury (ALI) Development." Current Signal Transduction Therapy 10.1 (2015): 48-55.
- The Human IL-33 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human IL-33 proteins within the range of 32-4000 pg/ml.