• 基因名称：
• IL1RN

• 蛋白名称：
• Interleukin-1 receptor antagonist protein

• Human Gene Id：
• 3557

• Human Swiss Prot No：
• P18510

• Mouse Swiss Prot No：
• P25085

• 特异性：
• Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

• 储存：
• 2-8°C/6 months

• 其他名称：
• IL1RN;IL1F3;IL1RA;Interleukin-1 receptor antagonist protein;IL-1RN;IL-1ra;IRAP;ICIL-1RA;IL1 inhibitor;Anakinra

• 检测方法：
• Colorimetric

• 背景：
• disease:Genetic variation in IL1RN is associated with susceptibility to diabetic nephropathy [MIM:612628]; also called susceptibility to microvascular complications of diabetes type 4 (MVCD4). Diabetic nephropathy is a kidney disease and resultant kidney function impairment due to the long standing effects of diabetes on the microvasculature (glomerulus) of the kidney. Features include increased urine protein and declining kidney function.,function:Inhibits the activity of IL-1 by binding to its receptor. Has no IL-1 like activity.,online information:Interleukin-1 entry,online information:The Singapore human mutation and polymorphism database,pharmaceutical:Available under the name Kineret (Amgen). Used for the reduction in signs and symptoms and slowing the progression of structural damage in moderately to severely active rheumatoid arthritis.,similarity:Belongs to the IL-1 family.,tissue specificity:The intracellular form of IL1RN is predominantly expressed in epithelial cells.,

• 功能：
• defense response, inflammatory response, immune response, response to wounding, response to endogenous stimulus, response to hormone stimulus, response to organic substance, response to corticosteroid stimulus,response to steroid hormone stimulus, response to glucocorticoid stimulus,

• 细胞定位：
• [Isoform 1]: Secreted.; [Isoform 2]: Cytoplasm.; [Isoform 3]: Cytoplasm.; [Isoform 4]: Cytoplasm.

• 组织表达：
• The intracellular form of IL1RN is predominantly expressed in epithelial cells.

Alpha-Momorcharin Inhibits Proinflammatory Cytokine Expression by M1 Macrophages but Not Anti-Inflammatory Cytokine Expression by M2 Macrophages Journal of Inflammation Research Fubing Shen ELISA Human
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