• 基因名称：
• EGF

• 蛋白名称：
• Pro-epidermal growth factor

• Human Gene Id：
• 1950

• Human Swiss Prot No：
• P01133

• Mouse Swiss Prot No：
• P01132

• 特异性：
• Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

• 储存：
• 2-8°C/6 months

• 其他名称：
• EGF;Pro-epidermal growth factor;EGF

• 检测方法：
• Colorimetric

• 背景：
• disease:Defects in EGF are the cause of hypomagnesemia type 4 (HOMG4) [MIM:611718]; also known as renal hypomagnesemia normocalciuric. HOMG4 is a disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to mederate psychomotor retardation, and brisk tendon reflexes.,function:EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.,online information:Epidermal growth factor entry,similarity:Contains 9 EGF-like domains.,similarity:Contains 9 LDL-receptor class B repeats.,tissue specificity:Expressed in kidney, salivary gland, cerebrum and prostate.,

• 功能：
• MAPKKK cascade, activation of MAPKK activity, angiogenesis, blood vessel development, morphogenesis of a branching structure, regulation of protein amino acid phosphorylation, vasculature development, DNA metabolic process, DNA replication, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process,regulation of mitosis, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, epidermal growth factor receptor signaling pathway, regulation of epidermal growth factor receptor activity, intracellular signaling cascade, protein kinase cascade, regulation of mitotic cell cycle, positive regulation of cell proliferation, positive regulation of signal transduction, regulation of receptor activity, positive regulation of phosphorus metabolic process, reg

• 细胞定位：
• Membrane; Single-pass type I membrane protein.

• 组织表达：
• Expressed in kidney, salivary gland, cerebrum and prostate.

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