• 基因名称：
• ADRBK1

• Human Gene Id：
• 156

• Human Swiss Prot No：
• P25098

• Mouse Swiss Prot No：
• Q99MK8

• Rat Swiss Prot No：
• P26817

• 储存：
• 2-8°C/6 months

• 其他名称：
• Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2)

• 检测方法：
• Colorimetric

• 背景：
• catalytic activity:ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate.,catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them.,online information:Beta adrenergic receptor kinase entry,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RGS domain.,subunit:Interacts with GIT1 (By similarity). Interacts with, and phosphorylates chemokine-stimulated CCR5.,tissue specificity:Expressed in peripheral blood leukocytes.,

• 功能：
• response to reactive oxygen species, regulation of the force of heart contraction, desensitization of G-protein coupled receptor protein signaling pathway, muscle system process, circulatory system process, heart process, regulation of the force of heart contraction by chemical signal, negative regulation of the force of heart contraction by chemical signal, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, muscle contraction, regulation of muscle contraction, striated muscle contraction, regulation of striated muscle contraction,response to oxidative stress, cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway, muscarinic acetylcholine receptor signaling pathway, tachykinin receptor signaling pathway, heart development, aging, blood circulation, regulation of heart contraction, regulation of G

• 细胞定位：
• Cytoplasm . Cell membrane . Cell junction, synapse, postsynapse . Cell junction, synapse, presynapse .

• 组织表达：
• Expressed in peripheral blood leukocytes.

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