Total RIPK2 Cell-Based Colorimetric ELISA Kit
- 货号：KA4270C
- 应用：ELISA
- 种属：Human;Mouse
- 其他名称：
- Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2)
- 背景：
- catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Activates pro-caspase-1 and pro-caspase-8. Potentiates CASP8-mediated apoptosis. Activates NF-kappa-B.,PTM:Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 CARD domain.,similarity:Contains 1 protein kinase domain.,subunit:Binds to CFLAR/CLARP and CASP1 via their CARD domains. Binds to BIRC3/c-IAP1 and BIRC2/c-IAP2, TRAF1, TRAF2, TRAF5 and TRAF6. May be a component of both the TNFRSF1A and TNRFSF5/CD40 receptor complex.,tissue specificity:Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.,
- 功能：
- cell activation, regulation of cytokine production, positive regulation of cytokine production, activation of innate immune response, pattern recognition receptor signaling pathway, toll-like receptor signaling pathway, response to molecule of bacterial origin, activation of immune response, immune response-activating cell surface receptor signaling pathway, positive regulation of immune system process, regulation of leukocyte activation, positive regulation of leukocyte activation, immune response-activating signal transduction, innate immune response-activating signal transduction, immune response-regulating signal transduction, immune response-regulating cell surface receptor signaling pathway, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process,apoptosis, anti-apoptosis, defense response, inflammatory response, cell surface receptor linked si
- 组织表达：
- Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.
