Total p47 phox Cell-Based Colorimetric ELISA Kit
- 货号：KA4210C
- 应用：ELISA
- 种属：Human
- 其他名称：
- Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox)
- 背景：
- disease:Defects in NCF1 are the cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 1 (CGD1) [MIM:233700]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.,function:NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).,online information:NCF1 deficiency database,similarity:Contains 1 PX (phox homology) domain.,similarity:Contains 2 SH3 domains.,subunit:Interacts with NOXA1.,
- 功能：
- oxygen and reactive oxygen species metabolic process, superoxide metabolic process, defense response, immune response, cellular defense response, superoxide anion generation, innate immune response, respiratory burst,
- 细胞定位：
- Cytoplasm, cytosol . Membrane ; Peripheral membrane protein ; Cytoplasmic side .
- 组织表达：
- Detected in peripheral blood monocytes and neutrophils (at protein level).
