Total MDM4 Cell-Based Colorimetric ELISA Kit
- 货号：KA4172C
- 应用：ELISA
- 种属：Human;Mouse;Rat
- 其他名称：
- Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4)
- 背景：
- alternative products:Additional isoforms seem to exist,domain:Region I is sufficient for binding p53 and inhibiting its G1 arrest and apoptosis functions. It also binds p73. Region II contains most of a central acidic region and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc mediates the heterooligomerization with MDM2.,function:Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation and apoptotic functions.,mass spectrometry: PubMed:11840567,similarity:Belongs to the MDM2/MDM4 family.,similarity:Contains 1 RanBP2-type zinc finger.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 SWIB domain.,subunit:Binds to p53, p73 and MDM2.,tissue specificity:In all tissues tested, with high levels in thymus.,
- 功能：
- negative regulation of transcription from RNA polymerase II promoter, re-entry into mitotic cell cycle, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein complex assembly,apoptosis, cell cycle, cell death, cell proliferation, positive regulation of cell proliferation, negative regulation of cell proliferation, negative regulation of biosynthetic process, regulation of catabolic process, negative regulation of catabolic process, negative regulation of macromolecule biosynthetic process, negative regulation of macromolecule metabolic process, posttranscriptional regulation of gene expression, negative regulation of gene expression,programmed cell death, death, negative regulation of transcription, cell cycle process, negative regulation of cellular biosynthetic process, regulation of protein stability, regulation of cell prolif
- 组织表达：
- Expressed in all tissues tested with high levels in thymus.
