Total Collagen IV α2 Cell-Based Colorimetric ELISA Kit

  • 货号：KA4046C
  • 应用：ELISA
  • 种属：Human;Mouse
    • 基因名称：
    • COL4A2
    • Human Gene Id：
    • 1284
    • Human Swiss Prot No：
    • P08572
    • Mouse Swiss Prot No：
    • P08122
    • 储存：
    • 2-8°C/6 months
    • 其他名称：
    • Collagen alpha-2(IV) chain [Cleaved into: Canstatin]
    • 检测方法：
    • Colorimetric
    • 背景：
    • domain:Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain.,function:Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Potently inhibits angiogenesis and tumor growth.,PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.,PTM:The trimeric structure of the NC1 domains may be stabilized by covalent bonds between Lys and Met residues.,PTM:Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.,similarity:Belongs to the type IV collagen family.,similarity:Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain.,subunit:There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network.,
    • 功能：
    • negative regulation of angiogenesis, extracellular matrix organization, extracellular structure organization, regulation of angiogenesis,
    • 细胞定位：
    • Secreted, extracellular space, extracellular matrix, basement membrane.

    相关报价

    • 货号：
    • KA4046C
    • 规格：
    • 96 / well
    • 价格：
    • ¥3300
    • 货期：
    • 预计发货时间为
      2024-08-01
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