ImmunoWay Biotechnology Company |抗体|病理抗体|诊断抗体

Total Adrenergic Receptor β2 Cell-Based Colorimetric ELISA Kit

背景：
disease:Polymorphic forms of ADRB2 could impart some form of nocturnal asthma.,function:Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.,PTM:Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation.,PTM:Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK. Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Binds SLC9A3R1 and GPRASP1.,

功能：
temperature homeostasis, tissue homeostasis, regulation of systemic arterial blood pressure by norepinephrine-epinephrine, response to dietary excess, diet induced thermogenesis, vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure, regulation of sodium ion transport, desensitization of G-protein coupled receptor protein signaling pathway, desensitization of G-protein coupled receptor protein signaling pathway by arrestin, circulatory system process, vascular process in circulatory system, regulation of systemic arterial blood pressure mediated by a chemical signal, regulation of systemic arterial blood pressure, negative regulation of systemic arterial blood pressure, regulation of nucleotide metabolic process, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein complex assembly

细胞定位：
Cell membrane ; Multi-pass membrane protein . Early endosome . Golgi apparatus . Colocalizes with VHL at the cell membrane (PubMed:19584355). Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325). Activated receptors are also detected within the Golgi apparatus (PubMed:27481942). .