Cleaved-PAR-4 (G48) Cell-Based Colorimetric ELISA Kit
- 货号：KA3975C
- 应用：ELISA
- 种属：Human
- 其他名称：
- Proteinase-activated receptor 4 (PAR-4) (Coagulation factor II receptor-like 3) (Thrombin receptor-like 3)
- 背景：
- function:Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.,PTM:A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets.,
- 功能：
- cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway, activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger,activation of phospholipase C activity, intracellular signaling cascade, blood coagulation, hemostasis, response to wounding, regulation of phospholipase activity, positive regulation of phospholipase activity, positive regulation of phospholipase C activity, second-messenger-mediated signaling, wound healing, positive regulation of catalytic activity, positive regulation of molecular function, phosphoinositide-mediated signaling, coagulation, regulation of body fluid levels, regulation of hydrolase activity, positive regulation of hydrolase activity, regulation of lipase activity,positive regulation of lipase activity,
- 细胞定位：
- Cell membrane; Multi-pass membrane protein.
- 组织表达：
- Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets.
