Cleaved-MMP-12 (G106) Cell-Based Colorimetric ELISA Kit

  • 货号：KA3966C
  • 应用：ELISA
  • 种属：Human
    • 基因名称：
    • MMP12
    • Human Gene Id：
    • 4321
    • Human Swiss Prot No：
    • P39900
    • Mouse Swiss Prot No：
    • P34960
    • 储存：
    • 2-8°C/6 months
    • 其他名称：
    • Macrophage metalloelastase (MME) (EC 3.4.24.65) (Macrophage elastase) (ME) (hME) (Matrix metalloproteinase-12) (MMP-12)
    • 检测方法：
    • Colorimetric
    • 背景：
    • catalytic activity:Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 4 calcium ions per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.,induction:By exposure to lipopolysaccharide. Inhibited by dexamethasone.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,tissue specificity:Found in alveolar macrophages but not in peripheral blood monocytes.,
    • 功能：
    • proteolysis, positive regulation of cell proliferation, regulation of cell proliferation, response to drug, regulation of epithelial cell proliferation, positive regulation of epithelial cell proliferation,
    • 细胞定位：
    • Secreted, extracellular space, extracellular matrix .
    • 组织表达：
    • Found in alveolar macrophages but not in peripheral blood monocytes.

    相关报价

    • 货号：
    • KA3966C
    • 规格：
    • 96 / well
    • 价格：
    • ¥3300
    • 货期：
    • 预计发货时间为
      2024-08-01
    订购

    相关产品