• 基因名称：
• AAK1

• Human Gene Id：
• 22848

• Human Swiss Prot No：
• Q2M2I8

• Mouse Swiss Prot No：
• Q3UHJ0

• Rat Swiss Prot No：
• P0C1X8

• 储存：
• 2-8°C/6 months

• 其他名称：
• AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1)

• 检测方法：
• Colorimetric

• 背景：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Stimulated by clathrin.,function:Phosphorylates the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2). May play a role in regulating aspects of clathrin-mediated endocytosis.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subcellular location:Active when found in clathrin-coated pits at the plasma membrane.,subunit:Interacts with alpha-adaptin and AP-2.,

• 功能：
• protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, phosphorylation,

• 细胞定位：
• Cell membrane ; Peripheral membrane protein . Membrane, clathrin-coated pit . Cell junction, synapse, presynapse . Active when found in clathrin-coated pits at the plasma membrane. In neuronal cells, enriched at presynaptic terminals. In non-neuronal cells, enriched at leading edge of migrating cells. .

• 组织表达：
• Detected in brain, heart and liver. Isoform 1 is the predominant isoform in brain.

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