Total IRF-4 Cell-Based Colorimetric ELISA Kit
- 货号：KA3743C
- 应用：ELISA
- 种属：Human;Mouse
- 其他名称：
- Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (Multiple myeloma oncogene 1) (NF-EM5)
- 背景：
- disease:A chromosomal aberration involving IRF4 may be a cause of multiple myeloma [MIM:254500]. Translocation t(6;14)(p25;q32) with the IgH locus.,function:Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.,induction:Not induced by interferons.,similarity:Belongs to the IRF family.,similarity:Contains 1 tryptophan pentad repeat DNA-binding domain.,subunit:Interacts with SPIB and DEF6.,tissue specificity:Lymphoid cells.,
- 功能：
- myeloid dendritic cell activation, cell activation, regulation of cytokine production, myeloid leukocyte activation, immune system development, leukocyte differentiation, myeloid leukocyte differentiation, regulation of leukocyte activation,chromatin organization, transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein amino acid acetylation, positive regulation of biosynthetic process, regulation of specific transcription from RNA polymerase II promoter, positive regulation of specific transcription from RNA polymerase II promoter, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, positive regulation of gene expression, chromatin modification, covalent chromatin modification, histone modification, histone acetylation, hemopoiesis, myeloid cell differen
