Total Mi2-β Cell-Based Colorimetric ELISA Kit
- 货号：KA3735C
- 应用：ELISA
- 种属：Human;Mouse
- 其他名称：
- Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.12) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta)
- 背景：
- disease:One of the main antigens reacting with anti-MI-2 positive sera of dermatomyositis.,function:Probable transcription regulator.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the SNF2/RAD54 helicase family.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,similarity:Contains 2 chromo domains.,similarity:Contains 2 PHD-type zinc fingers.,subunit:Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressor complex. Interacts with TRIM27. Part of a complex containing ATR and HDAC2. Interacts with KLF1; the interaction depends on sumoylation of KLF1, and leads to its transcriptional repression.,
- 功能：
- chromatin organization, chromatin assembly or disassembly, transcription, regulation of transcription, DNA-dependent,regulation of transcription from RNA polymerase II promoter, chromatin modification, regulation of transcription,regulation of RNA metabolic process, chromosome organization,
- 细胞定位：
- Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Associates with centrosomes in interphase. .
