Total Dyrk1A Cell-Based Colorimetric ELISA Kit
- 货号:KA3723C
- 应用:ELISA
- 种属:Human;Mouse;Rat
- 基因名称:
- DYRK1A
- Human Gene Id:
- 1859
- Human Swiss Prot No:
- Q13627
- Mouse Swiss Prot No:
- Q61214
- Rat Swiss Prot No:
- Q63470
- 储存:
- 2-8°C/6 months
- 其他名称:
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)
- 检测方法:
- Colorimetric
- 背景:
- alternative products:Additional isoforms seem to exist,catalytic activity:ATP + a protein = ADP + a phosphoprotein.,developmental stage:Expressed in the developing central nervous system.,disease:Overexpressed 1.5-fold in fetal Down syndrome brain.,enzyme regulation:Inhibited by RANBP9.,function:May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.,PTM:Autophosphorylated on tyrosine residues.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts RAD54L2/ARIP4 (By similarity). Interacts with RANBP9.,tissue specificity:Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.,
- 功能:
- protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, phosphorylation,peptidyl-tyrosine phosphorylation, peptidyl-tyrosine modification, protein amino acid autophosphorylation,
- 细胞定位:
- Nucleus . Nucleus speckle .
- 组织表达:
- Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.
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