• 基因名称：
• FOXE3

• Human Gene Id：
• 2301

• Human Swiss Prot No：
• Q13461

• Mouse Swiss Prot No：
• Q9QY14

• Rat Swiss Prot No：
• Q63250

• 储存：
• 2-8°C/6 months

• 其他名称：
• Forkhead box protein E3 (Forkhead-related protein FKHL12) (Forkhead-related transcription factor 8) (FREAC-8)

• 检测方法：
• Colorimetric

• 背景：
• disease:Defects in FOXE3 are a cause of anterior segment mesenchymal dysgenesis (ASMD) [MIM:107250]; also known as anterior segment ocular dysgenesis (ASOD). ASMD includes all malformations involving the first (corneal endothelium and trabecular meshwork), second (corneal stroma) and third (iris stroma) mesenchymal waves of neural crest. The ASMD phenotype is characterized by corneal opacities with or without iris adhesions in 100%, cataracts of varying severity in 100% and optic-nerve abnormalities in 20% of affected individuals.,disease:Defects in FOXE3 are a cause of congenital primary aphakia (CPA) [MIM:610256]. Human aphakia is a rare congenital eye disorder in which the lens is missing. It has been histologically subdivided into primary and secondary forms, in accordance with the severity of defects of the ocular tissues, whose development requires the initial presence of a lens. CPA results from an early developmental arrest, around the 4th-5th week of gestation in humans, that prevents the formation of any lens structure and leads to severe secondary ocular defects, including a complete aplasia of the anterior segment of the eye. In contrast, in secondary aphakic eyes, lens induction has occurred, and the lens vesicle has developed to some degree but finally has progressively resorbed perinatally, leading, therefore, to less-severe ocular defects.,similarity:Contains 1 fork-head DNA-binding domain.,

• 功能：
• eye development, transcription, transcription, DNA-dependent, regulation of transcription, DNA-dependent,transcription from RNA polymerase II promoter, sensory organ development, positive regulation of cell proliferation,RNA biosynthetic process, regulation of cell proliferation, regulation of transcription, regulation of epithelial cell proliferation, positive regulation of epithelial cell proliferation, regulation of RNA metabolic process,

• 细胞定位：
• Nucleus .

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