Total Mat1 Cell-Based Colorimetric ELISA Kit
- 货号：KA3628C
- 应用：ELISA
- 种属：Human;Mouse;Rat
- 其他名称：
- CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Cyclin-G1-interacting protein) (Menage a trois) (RING finger protein 66) (RING finger protein MAT1) (p35) (p36)
- 背景：
- function:Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 UIM (ubiquitin-interacting motif) repeat.,subunit:Associates primarily with CDK7 and cyclin H to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.,tissue specificity:Highest levels in colon and testis. Moderate levels are present thymus, prostate, ovary, and small intestine. The lowest levels are found in spleen and leukocytes.,
- 功能：
- regulation of cyclin-dependent protein kinase activity, G1/S transition of mitotic cell cycle, mitotic cell cycle, nucleotide-excision repair, DNA damage removal, DNA metabolic process, DNA repair, nucleotide-excision repair, DNA catabolic process, transcription, transcription, DNA-dependent, transcription initiation, RNA elongation, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter, transcription initiation from RNA polymerase II promoter, RNA elongation from RNA polymerase II promoter, protein complex assembly, response to DNA damage stimulus, cell cycle, heart development,adult heart development, cell proliferation, positive regulation of cell proliferation, macromolecule catabolic process,positive regulation of biosynthetic process, response to inorganic substance, response to metal i
- 组织表达：
- Highest levels in colon and testis. Moderate levels are present thymus, prostate, ovary, and small intestine. The lowest levels are found in spleen and leukocytes.
