Total CLK2 Cell-Based Colorimetric ELISA Kit
- 货号：KA3619C
- 应用：ELISA
- 种属：Human;Mouse;Rat
- 其他名称：
- Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2)
- 背景：
- catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates serines, threonines and tyrosines.,PTM:Autophosphorylates on all three types of residues.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.,similarity:Contains 1 protein kinase domain.,
- 功能：
- protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, phosphorylation,
- 细胞定位：
- Nucleus .; [Isoform 1]: Nucleus . Nucleus speckle . Inhibition of phosphorylation at Ser-142 results in accumulation in the nuclear speckle. .; [Isoform 2]: Nucleus speckle . Co-localizes with serine- and arginine-rich (SR) proteins in the nuclear speckles. .
- 组织表达：
- Endothelial cells (PubMed:19168442). Expressed in androgen-dependent prostate cancer cells (PubMed:28289210).
