• 基因名称：
• BCAR3

• Human Gene Id：
• 8412

• Human Swiss Prot No：
• O75815

• Mouse Swiss Prot No：
• Q9QZK2

• 储存：
• 2-8°C/6 months

• 其他名称：
• Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B)

• 检测方法：
• Colorimetric

• 背景：
• function:May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins.,PTM:Phosphorylated on tyrosine.,similarity:Contains 1 Ras-GEF domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with BCAR1, NEDD9, PTK2 and PTPN1.,tissue specificity:Ubiquitously expressed. Found in several cancer cell lines, but not in nonmalignant breast tissue.,

• 功能：
• intracellular signaling cascade, small GTPase mediated signal transduction, response to drug,

• 细胞定位：
• Cytoplasm . Cell junction, focal adhesion . Localization to focal adhesions depends on interaction with PTPRA. .

• 组织表达：
• Ubiquitously expressed. Found in several cancer cell lines, but not in nonmalignant breast tissue.

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